DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) first isolated from rabbit cerebral venous blood in 1974, studied for its role in neuroendocrine signaling, hypothalamic-pituitary axis regulation, and sleep architecture research. Published research spanning five decades has characterized DSIP as a neuropeptide small enough to cross the blood-brain barrier directly — a property that distinguishes it from larger peptides in CNS research applications. Studies have examined DSIP's capacity to attenuate corticotropin-releasing factor (CRF) signaling, buffering stress-axis feedback mechanisms in research models. Additional research has explored its influence on LH, GH, and TSH secretion patterns in neuroendocrine research settings, suggesting a compound with broad hypothalamic-pituitary regulatory effects in preclinical studies. Research has also examined DSIP's role in slow-wave sleep architecture in animal models, where it was first characterized. These sleep architecture effects have been studied alongside its stress-axis modulation properties in research examining the intersection of neuroendocrine function and sleep physiology. For researchers studying hypothalamic-pituitary axis regulation, neuroendocrine signaling, or sleep architecture mechanisms, DSIP offers one of the longest-standing research profiles among naturally occurring neuropeptides. For research use only.

DSIP is a naturally occurring nonapeptide studied for its role in hypothalamic-pituitary neuroendocrine signaling and cortisol modulation in research models. First characterized in 1974, it has accumulated over 50 years of published research on sleep architecture regulation and stress-axis hormones. 99% purity. For research use only. Available as Lyophilized powder. Sold in 10mg units. Every batch is independently third-party tested: HPLC purity confirmed at ≥99%, with mass spectrometry identity verification. A batch-specific Certificate of Analysis (COA) ships with every order. US-based supplier with same-day dispatch on orders before the daily cutoff (HST). For research use only. Not for human consumption.