Buy DSIP | Research Grade Peptide | ≥99% Purity | COA Included
DSIP is a naturally occurring neuropeptide your brain produces, studied for over 50 years for its role in delta-wave sleep induction and stress-axis normalization. It just does not produce enough of it when chronic stress keeps cortisol elevated and sleep architecture shallow. 99% pure. Available as Lyophilized powder. Sold in 10mg units. Every batch is independently third-party tested: HPLC purity confirmed at ≥99%, with mass spectrometry identity verification. A batch-specific Certificate of Analysis (COA) ships with every order. US-based supplier, ships within 24 hours.
DSIP
10mg · Lyophilized powder
Amino Acid Sequence
Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
💡 Buy 3 or more — save 10% automatically
≥99% Purity
Third-party HPLC & MS verified
Delta Wave Research
Studied for slow-wave sleep promotion
HPA Axis Modulation
Attenuates stress-driven cortisol elevation
BBB-Permeable
Small nonapeptide with CNS research utility
Molecular Data
Formula
C₃₅H₄₈N₁₀O₁₅
Molecular Weight
848.81 g/mol
Frequently Bought Together
DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) first isolated in 1974, studied for its role in inducing slow-wave sleep, modulating stress-axis hormones, and regulating hypothalamic-pituitary function. Slow-wave sleep is where your brain consolidates memory, your pituitary releases growth hormone, and your immune system runs its deepest repair cycles. It is also the stage most disrupted by stress, aging, and the cortisol patterns that modern life produces almost universally. Delta Sleep-Inducing Peptide was first isolated from rabbit cerebral venous blood in 1974 after researchers observed it inducing slow-wave sleep in animal models with unusual consistency. What followed was five decades of investigation that progressively widened its profile. DSIP is a nonapeptide small enough to cross the blood-brain barrier directly, a property that makes it relevant to CNS research in ways that larger peptides simply cannot match. Studies have examined its capacity to attenuate corticotropin-releasing factor, effectively buffering the stress-axis feedback loop that keeps cortisol elevated and restorative sleep out of reach. Additional research has explored its influence on LH, GH, and TSH secretion, suggesting a compound that does not simply act on sleep but on the neuroendocrine environment that sleep depends on. For researchers studying the intersection of stress physiology and sleep architecture, DSIP represents one of the few naturally occurring peptides with a research profile spanning both.
Researcher Reviews
Share your research experience
Sign in to leave a review
Frequently Asked Questions
Related Products
DSIP— Specifications & Quality Standards
Certificate of Analysis: What We Test
HPLC Purity Analysis
Every batch of DSIP is run through High-Performance Liquid Chromatography. The chromatogram confirms purity percentage and identifies any impurity peaks. Our minimum standard is ≥98%; flagship compounds test at ≥99%.
Mass Spectrometry (MS)
Mass spec confirms the molecular weight of DSIP matches the theoretical value exactly. This verifies the compound identity, confirming it is not a substitute or mislabeled product.
Endotoxin Screening
Endotoxin testing ensures the compound is free from bacterial contamination. Combined with HPLC purity and MS identity confirmation, this is the full three-point verification used by accredited research labs.
Want to understand how to read a COA? Read our COA guide.
DSIP: Frequently Asked Questions
What is DSIP?
DSIP, or Delta Sleep-Inducing Peptide, is a naturally occurring nonapeptide first identified in 1974. It is studied for its ability to induce slow-wave (delta) sleep, modulate cortisol secretion, and influence the secretion of LH, GH, and TSH.
How does DSIP affect sleep?
Research has shown DSIP promotes delta-wave sleep by modulating hypothalamic signaling and attenuating corticotropin-releasing factor activity, which reduces the cortisol elevation that disrupts restorative sleep architecture.
Can DSIP cross the blood-brain barrier?
Yes. DSIP is a small nonapeptide with the molecular size and properties to cross the blood-brain barrier directly, which is a key feature distinguishing it from larger peptides in CNS-related research.
What hormones does DSIP affect?
Studies have examined DSIP's influence on the secretion of LH, GH, TSH, and ACTH, as well as its attenuation of corticotropin-releasing factor, making it relevant to both sleep and broader neuroendocrine research.
Is DSIP for human use?
No. DSIP from Blackwell BioLabs is sold strictly for laboratory and research purposes. It is not approved for human consumption or therapeutic use.
More questions? Contact our team or visit our full FAQ page.
Research Resources




