MOTS-c is a mitochondria-derived regulatory peptide encoded within the 12S rRNA region of mitochondrial DNA, functioning as an intracellular signaling molecule between the mitochondria and nucleus. Discovered less than a decade ago, MOTS-c is encoded directly in mitochondrial DNA and operates as a stress-response signal. When cellular energy stress occurs, MOTS-c travels to the nucleus and activates AMPK-dependent signaling cascades — the enzyme researchers associate most closely with metabolic adaptation and longevity-associated gene expression. Research models demonstrate effects on mitochondrial efficiency, cellular metabolic flexibility, and the expression of longevity-associated markers. Studies have examined its role in AMPK activation, exercise physiology models, and the biology of cellular aging. MOTS-c represents a relatively new class of peptide encoded by organellar rather than nuclear DNA. For researchers studying mitochondrial signaling, metabolic adaptation mechanisms, or longevity biology, MOTS-c offers an unusual research profile — a compound that acts as both a cellular stress sensor and a transcriptional activator. For research use only.

MOTS-c is a mitochondria-derived peptide encoded in mitochondrial DNA, studied for its role in AMPK pathway activation and mitochondrial stress response signaling. Research models examine its effects on cellular metabolic adaptation, mitochondrial efficiency, and longevity-associated gene expression markers. 99% purity. For research use only. Available as Solution. Sold in 40 mg / 3 mL vial units. Every batch is independently third-party tested: HPLC purity confirmed at ≥99%, with mass spectrometry identity verification. A batch-specific Certificate of Analysis (COA) ships with every order. US-based supplier with same-day dispatch on orders before the daily cutoff (HST). For research use only. Not for human consumption.