Cells have been sending this signal all along. MOTS-c is a mitochondrial messenger that switches on the body's metabolic survival pathways, studied for insulin sensitivity, energy production, and healthy aging. One of the most significant longevity research discoveries of the last decade. Available as Solution. Sold in 40 mg / 3 mL vial units. Every batch is independently third-party tested: HPLC purity confirmed at ≥98%, with mass spectrometry identity verification. A batch-specific Certificate of Analysis (COA) ships with every order. US-based supplier, ships within 24 hours.
MOTS-c
40 mg / 3 mL vial · Solution
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AMPK Activation
Metabolic master switch via AICAR
Mitochondrial Origin
Encoded in mitochondrial DNA
≥98% Purity
Third-party HPLC & MS verified
Longevity Research
Active aging biology domain
Certificate of Analysis
AvailableThird-party verified. Click to view the full lab report.
View Lab Report →For research use only. Not for human consumption, veterinary use, or clinical application. Not evaluated or approved by the FDA for any therapeutic or diagnostic purpose. By purchasing, you confirm you are a qualified researcher acquiring this compound for legitimate in-vitro or laboratory research.
Molecular Weight
2174.68 g/mol
Research Guide
Mitochondrial Peptides: MOTS-c & SS-31
Your mitochondria — the tiny power generators inside every cell — do not just produce energy. They send signals. And MOTS-c is one of those signals. Discovered less than a decade ago, MOTS-c is encoded directly in your mitochondrial DNA and acts as an emergency broadcast to the rest of your body: adapt, survive, and burn. When cellular stress occurs, MOTS-c travels to the nucleus and activates a cascade of survival genes — increasing metabolic flexibility, improving how your cells process glucose, and switching on AMPK, the enzyme researchers associate most closely with longevity. In plain language: it makes your body's energy system more efficient and more resilient at the exact same time. Researchers are studying it for insulin resistance, metabolic syndrome, physical performance, and the biology of healthy aging. One of the most exciting discoveries in the longevity space over the last decade — and it was inside us the entire time.
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Every batch of MOTS-c is run through High-Performance Liquid Chromatography. The chromatogram confirms purity percentage and identifies any impurity peaks. Our minimum standard is ≥99% by HPLC, verified by accredited third-party laboratories on every production batch.
Mass spec confirms the molecular weight of MOTS-c matches the theoretical value exactly. This verifies the compound identity, confirming it is not a substitute or mislabeled product.
Endotoxin testing ensures the compound is free from bacterial contamination. Combined with HPLC purity and MS identity confirmation, this is the full three-point verification used by accredited research labs.
Want to understand how to read a COA? Read our COA guide.
Read our in-depth research guide for MOTS-c: mechanism of action, relevant studies, research protocols, and storage guidelines.
Read the MOTS-c Research GuideOne of only a handful of known mitochondrial-derived peptides.
Sterile solution (40mg/3mL). No reconstitution required.
By inhibiting the folate-methionine cycle, causing AICAR accumulation.
Metabolic syndrome, insulin resistance, exercise physiology, aging biology.
Store at -20°C. Stable for 24 months in original sealed vial.
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